How does interferon inhibit viruses

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The transcription factor STAT-1 couples macrophage synthesis of hydroxycholesterol to the interferon antiviral response. Interferon-inducible cholesterolhydroxylase restricts hepatitis C virus replication through blockage of membranous web formation.

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J Infect Dis. The V protein of human parainfluenza virus 2 antagonizes type I interferon responses by destabilizing signal transducer and activator of transcription 2. Identification of the nuclear export signal and STAT-binding domains of the Nipah virus V protein reveals mechanisms underlying interferon evasion. Measles virus suppresses interferon-alpha signaling pathway: suppression of Jak1 phosphorylation and association of viral accessory proteins, C and V, with interferon-alpha receptor complex.

The amino-terminal extensions of the longer Sendai virus C proteins modulate pYStat1 and bulk Stat1 levels independently of interferon signaling. The STAT2 activation process is a crucial target of Sendai virus C protein for the blockade of alpha interferon signaling.

IFN-alpha antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway. J Immunol. Curr Opin Immunol. Redirection of silencing targets by adenosine-to-inosine editing of miRNAs. Nat Struct Mol Biol.

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